PD模型:
大鼠6—OHDA诱导的PD模型
MPTP诱导小鼠模型
A53T synuclein转基因小鼠PD模型
A53T 黑质过表达诱导PD模型(大鼠小鼠)
PFF脑内诱导的PD模型(大鼠小鼠)
PFF胃壁诱导PD模型(大鼠小鼠)
AD模型
app/ps1转基因模型
5X FAD 转基因模型
Abeta诱导AD模型
(1)帕金森病模型—OB(嗅球)立体A-hm-α-syn
给方式:立体; 部位:嗅球; 周期:12周。
The number of times crossing the line and the total distance treled were lower 6 wee after the A-hm-α-syn injection.
(2)OB(嗅球)立体A-hm-α-syn
A:Presention of the TH-positive cells in the strium and SN 12 wee after injection into the OB.
B&C:The number of TH-positive cells bodies and terminals in the SN-strium fields is reduced 12 wee after A-hm-α-syn injection.
D&E:DA and DOPAC level in the SN-strium fields is reduced 12 wee after A-hm-α-syn injection.
(3)OB(嗅球)立体A-hm-α-syn
Overpression of the Hm-α-syn by the A injection
(4)帕金森病模型—MPTP模型及A53T模型
慢性MPTP诱导PD模型(小鼠):
给方式:腹腔;周期:20天;
给剂量:Day1-2(10mg/kg),Day3-4(15mg/kg),Day5-6(20mg/kg),Day7-20(25mg/kg)。
Time spend in Beam trersal test is reduced after MPTP injection and in A53T mice.
Mice after MPTP injection and A53T mice fall more easily in Rotarod test.
(5)帕金森病模型—PFF诱导模型
给方式:立体; 部位:纹状体(5μg/side); 周期:12周。
(6)帕金森病模型—6-OHDA诱导模型(大鼠)
给方式:立体; 部位:黑质、纹状体(20μg/8μl,SN/Str各4μl); 周期:2周。
阿扑吗啡-不对称旋转测试:腹腔APO-0.5mg/kg
阿朴吗啡诱导旋转行为阳性时,大鼠多以旋转侧前肢为支撑点向损伤对侧的原地转动。动物的旋转行为监测持续30min,超过5次/min,作为PD建模成功的定量指标。